We've highlighted the enfumafungin medicinal chemistry program previously at this site. Recently, a new series of semisynthetic antifungal glucan synthase inhibitors were disclosed in Bioorganic and Medicinal Chemistry Letters (currently In Press, 2012). I'm clearly not an unbiased observer in this case, but I would suggest that if you are interested in structurally complex bioactive terpenoid derivatives then this manuscript is probably worth taking a look at.
Driven by the great medicinal potential of the steroidal sex hormones and anti-inflammatory agents, the period of the 1930s through the 1950s has been called the golden age of steroid chemistry. In recent years, steroid research has witnessed a renaissance, as a new generation of scientists has begun to recognize the pharmacologically privileged nature of the steroidal molecular framework. This blog highlights achievements pertaining to steroid technologies published from 2010 to the present.
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