Saturday, July 7, 2012
Semisynthetic Terpenoid Antifungal Agents from Scynexis and Merck (part 2)
We've highlighted the enfumafungin medicinal chemistry program previously at this site. Recently, a new series of semisynthetic antifungal glucan synthase inhibitors were disclosed in Bioorganic and Medicinal Chemistry Letters (currently In Press, 2012). I'm clearly not an unbiased observer in this case, but I would suggest that if you are interested in structurally complex bioactive terpenoid derivatives then this manuscript is probably worth taking a look at.