We've highlighted the enfumafungin medicinal chemistry program previously at this site. Recently, a new series of semisynthetic antifungal glucan synthase inhibitors were disclosed in Bioorganic and Medicinal Chemistry Letters (currently In Press, 2012). I'm clearly not an unbiased observer in this case, but I would suggest that if you are interested in structurally complex bioactive terpenoid derivatives then this manuscript is probably worth taking a look at.
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